Methylene Blue

Explore methylene blue only through careful clinician screening and a clearly defined treatment plan.

What it is: Methylene blue is an FDA-approved injectable medicine for acquired methemoglobinemia, a specific blood disorder. It is also promoted off-label for cognitive, mitochondrial, or energy-related goals.

Important to know: Methylene blue can act as a monoamine oxidase inhibitor and may cause a dangerous serotonin reaction when combined with many antidepressants and other serotonergic drugs. It can also discolor urine or stool and may be unsafe for people with G6PD deficiency, pregnancy, or certain kidney conditions. A clinician must review all medications and supplements before prescribing.